Here is the save file location for on each major platform. Windows (Steam) The save files are located in your Player Data folder, not the game’s install directory.
%LOCALAPPDATA%\Microsoft\WindowsApps\slay.the.spire_2j6cbj3kzxpc6\LocalCache\Local\SlayTheSpire\ However, because WindowsApps folders are often locked, the (for standard Steam installs) is actually: slay the spire save file location
~/.var/app/com.valvesoftware.Steam/.local/share/SlayTheSpire/ In Desktop Mode: Here is the save file location for on each major platform